Quantification of tumor area showed an even more striking effect than in PDAC: both tumor burden relative to whole lung epithelium and tumor number were dramatically reduced by BET inhibitor treatment (7.72±4.17% vs 0.45±0.60% and an average of 10±3 vs 2±1 tumors per animal, in untreated versus treated animals respectively) (Figure 1D). Here, DNER is linked to neoplasm.