As IH has been shown to induce insulin resistance [47], in agreement with an elevation of serum glucose level in IH-exposed rats (Supplementary Figure S3), the findings that downregulated expressions of IGF-1R pathway in both IH-exposed differentiated HPAs (mature adipocytes) and adipose tissue (SAT and VAT) provide novel mechanistic insight into the relationship between IH and insulin resistance of mature adipocytes. The gene discussed is INS; the disease is Insulin resistance.