CDX2 and bladder urachal adenocarcinoma: However, nuclear CDX2 reactivity was evident in the majority of urachal adenocarcinomas (90%) [1, 17, 23, 26, 31, 60, 99, 125, 126, 128, 216, 217, 240, 245, 251, 327, 330] and many primary bladder adenocarcinomas (13%–83%) [329, 331].