Low numbers of cases and no differential diagnostic value regarding the discrimination of urachal adenocarcinomas from primary bladder and colorectal adenocarcinomas were detected for α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), cluster of differentiation 10 (CD10), CK19, Das-1, E48, E-Cadherin, gross cystic disease fluid protein 15 (GCDFP15), mucin 1 (epithelial membrane antigen) (MUC1 (EMA)), mucin 6 (MUC6), Thrombmodulin, thyroid transcription factor 1 (TTF1), Uroplakin III, Villin, and Vimentin [27, 48, 60, 86, 100, 106, 125, 126, 172, 198, 215, 217, 245, 292, 330]. The gene discussed is PIP; the disease is colorectal adenocarcinoma.