Two CpGs passed the threshold for Bonferroni correction (Fig. 1a and Table 2), including a hypo-methylated CpG (cg17580798) in the MEST promoter (chr7:130132199, p = 1.35E-07) and cg23117250 (chr17: 80649886, intronic, p = 1.55E-07) that is located in an intron of RAB40B. RAB40B encodes for a poorly characterized protein proposed to be involved in vesicle transport [35] and cancer progression [36]. The gene discussed is MEST; the disease is cancer.