However, in view of potential role of ozone in cancer treatment, we were interested to demonstrate if ozone could determine cell death in human colon cancer cell line and its possible anti-inflammatory properties based on modulation of cytokines secretion by cancer cells, considering the central role of several small molecules like IL-8 and IL-6 in colon cancer cell survival and chemoresistance [10]. This evidence concerns the gene IL6 and colonic neoplasm.