(b) These results emphasize the roles of AbdAT miRNAs (i.e., miR-24, miR-30d, and miR-146a) and SFRP4 in regulating mechanisms that govern AbdAT remodeling and systemic insulin sensitivity in obesity and T2DM. Here, SFRP4 is linked to obesity due to melanocortin 4 receptor deficiency.