Remarkably, our published studies profiling circulating miRNAs in independent cohorts covering the full diabetes spectrum [including prediabetes, T2DM, latent autoimmune diabetes of adults (LADA), and type 1 diabetes] have identified these three miRNAs among characteristic signatures that differentially correlate with clinical measures and indices of glycemic control, insulin resistance, and beta cell function and allow for fairly sensitive and specific classification of diabetes subtypes [16, 28]. Here, INS is linked to type 2 diabetes mellitus.