Now, using samples from the same parent study cohort, we have uncovered new evidence that supports the existence of obesity- and T2DM-related mechanisms that upregulate the production of the secreted antiangiogenic factor SFRP4 in the AbdAT, in close association with the expression of fat tissue-derived miRNAs (specifically miR-30d, miR-146a). Here, SFRP4 is linked to obesity due to melanocortin 4 receptor deficiency.