Given that in our kinetic analysis we saw increases in both frequency of CD69 expression and IFN-γ levels at five to 10 h after KRN administration, and our understanding of IFN-γ as a proinflammatory cytokine, this synergistically detrimental effect at 10 h following sepsis induction and KRN administration is not surprising. This evidence concerns the gene IFNG and Sepsis.