IL1B and Sepsis: At 10 h after sepsis induction, there was no difference in levels of the proinflammatory cytokines IL-6 or IL-1β between vehicle- and KRN-pretreated pups (41 ± 13 vs. 39 ± 5 ng/ml and 162 ± 58 vs. 199 ± 55 pg/ml, respectively; Figures 5A,B).