OGT and Hyperglycemia: Based on OGT siRNA data, the ability of miR-200a/200b mimics to downregulate OGT expression and O-GlcNAcylation levels may act as a possible mechanism to attenuate hyperglycemia-induced endothelial inflammation by regulating nuclear factor-kB activity (James et al., 2002; Yang et al., 2008; Allison et al., 2012).