For GSTs, the protective role toward cytotoxicity or mutagenicity has been shown for many xenobiotics, including environmental carcinogens, such as polycyclic aromatic hydrocarbons (Hu et al., 1999; Ahmad et al., 2008; Kabler et al., 2009), anti-tumor alkylating agents, such as doxorubicin (O’Brien et al., 2000; Tashiro et al., 2001) and cisplatin (Peklak-Scott et al., 2008), and hepatotoxic drugs such as diclofenac (Al-Attrache et al., 2016), isoniazid and acetaminophen (Tolosa et al., 2017). The gene discussed is HPGDS; the disease is neoplasm.