mRNA expression data of miR-449a and GPR158 were confirmed on 25 frozen glioma samples and 5 CNS samples from our own collection (miR-449a: CNS, n = 5; O, n = 7; A, n = 7; GBM, n = 8; and GPR158 CNS, n = 5; O, n = 8; A/GBM-IDH, n = 8; GBM, n = 9) (Figs. 7b, c) by RT-qPCR analysis. This evidence concerns the gene IDH2 and glioblastoma.