In 29 other TCGA tumour entities (Supplementary Figure 3D), with the exception of pheochromocytoma and paraganglioma [45], the remaining tumours types expressed very little or no GPR158. In conclusion, we show here that there is a statistically significant difference of GPR158 expression between clinically and biologically distinct glioma subgroups, and GPR158 expression was specific in nervous system-related tumours. Here, GPR158 is linked to central nervous system cancer.