In keeping with these observations, the expression analysis with the mouse Profiler PCR Array showed a significant up-regulation of Map2, Sox2, and Pdgfra (Fig. 4q) in Gpr158 expressing cells, and corresponding protein expression in tumours developing from allografted cells in vivo (Fig. 6), thus further strengthening the correlation of our experimental data with clinical outcome data. This evidence concerns the gene SOX2 and neoplasm.