DRD2 and serotonin syndrome: (2) A well-balanced combination of dopamine receptors and serotonin receptors confers a favourable behavioural profile on PCC0104005, characterized by efficacy in models predictive of antipsychotic activity (dopamine D2 receptor partial agonism), together with a lack of cataleptogenic activity or serotonin syndrome induction (3) PCC0104005 alone had no detrimental effect on these locomotor hyperactivity model.