SEMA3A and neoplasm: It is important to note that neither exogenous nor tumour-derived Sema3A had an effect on the viability or growth of primary calvarial osteoblasts and the osteoblast-like cells MC3T3 and Saos-2 after up to 12 (Saos-2), 25 and 28 (MC3T3 and calvarial osteoblasts) days (Figure S5).