SEMA3A and osteosarcoma: Exposure of osteoblast-like cells MC3T3, the more differentiated human osteosarcoma cells MG-63 and Saos-2 and the highly metastatic MNNG/HOS and KHOS cells to exogenous Sema3A (300 ng/ml) had no effect on their viability after 48 hours (Supplementary Figure S1).