LEP and obesity due to melanocortin 4 receptor deficiency: Importantly, the obesity-stratified logistic regression analysis adjusted for age, sex and tPa also confirmed that lower adiponectin (OR, 0.49; 95% CI, 0.38–0.64) and higher leptin (OR, 1.41; 95% Cl, 1.25–1.58) levels were predictors for PTS (Supplementary Table 4).