The analysis of the patients after exclusion of those with recurrent DVT during follow-up after adjustment for age, sex, obesity and tPa also showed that decreased adiponectin (OR, 0.44; 95% CI, 0.32–0.63) and increased leptin (OR, 1.46; 95% CI, 1.26–1.69) predicted PTS in patients free of VTE recurrences. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.