In both healthy and chronic inflamed (AOM/DSS week 7) WT mice (Fig. 2A a-b), colon Cygb-ir is localized to fibroblast-like interstitial cells surrounding the crypts of the mucosal glands, interstitial fibroblast cells of the submucosa, and interstitial Cajal-like cells of the tunica muscularis. Here, CYGB is linked to infectious otitis media.