Thus, inflammation-related genes, such as those for CCL9, CXCL1, CXCL2, CXCL10, MMP3, MMP8, MMP9, MMP10, MMP13 and IL-17a, demonstrated increased expression in Cygb-deficient mice during AOM/DSS-induced colitis. Here, MMP8 is linked to infectious otitis media.