CYGB and colonic neoplasm: Cygb-deficient mice developed a significant increased number of colonic tumors (mean ± standard error of the mean (SEM) = 14.5 ± 1.186, n = 10) compared with WT mice (mean ± SEM = 9.25 ± 1.244, n = 12) following the AOM/DSS regimen, primarily in the distal part of the colon (Fig. 8a).