Results of our proteomic profiling allowed the identification of several proteins supporting abnormal PTEN function: increased LMCD1 has been linked to tumor metastasis8 and ITA3 is involved in promoting cell invasion.21 In addition, we detected increased AK2, a negative regulator of tumor cell growth,9 indicating a compensatory effect, and may explain why extensive tumor screen did not detect malignant processes in our patient. This evidence concerns the gene AK2 and neoplasm.