Moreover, the crucial pathogenic role of FcγRs has been proven in a multitude of experimental arthritis models, such as collagen-induced arthritis (CIA), glucose-6-phosphate isomerase-induced arthritis, collagen type II antibody-induced arthritis, the K/B×N serum transfer model, IC arthritis, and antigen-induced arthritis (AIA) models. The gene discussed is GPI; the disease is arthritic joint disease.