Accordingly, the ability of ACT-333679 to significantly reduce the phosphorylation of both Erk1/2 and Akt in cultured SSc fibroblasts/myofibroblasts found in our study, seems to further suggest that the effects of this IP receptor agonist on these cells might involve downregulation in the profibrotic signaling pathways. Here, AKT1 is linked to systemic sclerosis.