FBXO32 and Distal myopathy, Nonaka type: Moreover, the authors provided molecular insights into the associated muscle fibre degeneration by demonstrating that two well-known muscle atrophy markers (atrogin-1/Fbxo32 and MuRF1/Trim63) present with elevated transcript level in the diseased murine muscle fibres, suggesting that common proteolytic systems of muscle atrophy are involved in the pathophysiology of GNE myopathy [68].