Mutations in the genes that encode proteins involved in LDL uptake and catabolism, the LDL-receptor (LDLR), apolipoprotein-B (APOB), LDL receptor adaptor protein (LDLRAP1) and PCSK9 (PCSK9) are known to cause FH, resulting from defective LDL uptake and degradation. The gene discussed is LDLRAP1; the disease is familial hyperaldosteronism.