Advances in microarray and sequencing technologies have identified genetic biomarkers of CLL as recurrent copy number abnormalities (CNAs), including del13q14, del11q22–23, del17p, trisomy-12, and frequent point mutations in SF3B1, NOTCH1, BIRC3 and other genes [4]. Here, SF3B1 is linked to B-cell chronic lymphocytic leukemia.