POT1 was the most frequently mutated gene in UR-CLL (25%), followed by NOTCH1, RB1 (19% each), ATM, APC, MED12, SF3B1, and KMT2C (13% each) (Fig. 1a and Additional file 1: Table S2). This evidence concerns the gene POT1 and B-cell chronic lymphocytic leukemia.