UN-CLL tumors were enriched for mutations in genes with roles in epigenetic regulation (EP300, ARID1B, ZMYM3, KMT2C) and the Ras/MAPK signaling pathway (FLT4, MET, EPHA7, MAP3K1), consistent with previous studies (Fig. 1b) [23]. Here, FLT4 is linked to B-cell chronic lymphocytic leukemia.