Recent in vivo pharmacologic studies in healthy dogs [25, 27] have provided support for development of ATR-101 in ACC and endocrine diseases such as CS and congenital adrenal hyperplasia given that ATR-101 preferentially distributes to the adrenal glands and selectively inhibits adrenal ACAT1 activity. The gene discussed is ACAT1; the disease is congenital adrenal hyperplasia.