To understand the reason behind the decreasing rates over time, the reader should be aware that the study period encompasses three phases of BC’s response to HIV/AIDS: the harm reduction and health service scale-up phase (2000–2005); the early Treatment as Prevention phase (2006–2009); and the STOP HIV/AIDS phase (2010-present), during which BC’s HIV therapeutic guidelines recommended ART treatment for all adults with HIV infection, regardless CD4 count [45, 46]. The gene discussed is CD4; the disease is AIDS.