Although CRBP-1 has been found overexpressed in Talbot’s, Estilo’s and Ye’s datasets in TSCC and Cromer’s, Peng’s, Toruner’s and Ginos’ data sets in HNSCC through microarray studies, but no one of them deepened their researches to dig out the relationship between CRBP-1 expression and the prognosis of TSCC patients and the role of CRBP-1 in TSCC cell lines. Here, RBP1 is linked to head and neck squamous cell carcinoma.