A similar loss of MIST1 and PTF1a proteins is observed in murine PDAC cell lines derived from KC and KPC mice (KC, KPC1, KPC2) as well as from human PDAC tumors (BxPC‐3, Panc‐1, MiaPaCa‐2) (Fig. 1D). Here, RNF123 is linked to keratoconus.