In details, in estrogen receptor (ESR) negative SkBr3 breast cancer cells (Lappano et al., 2017), as well as in ESR positive endometrial Ishikawa tumor cells, the expression of the SLC37A1 transcript was proven to be upregulated by the epidermal growth factor (EGF), through the EGF receptor/mitogen-activated protein kinase/Fos transduction pathway. The gene discussed is ESR1; the disease is breast cancer.