In detail, a mutation in this gene was found in one patient with CHI in which the molecular basis of the disease remained unknown, highligting that it could be responsible for the dysregulation of insulin secretion (Proverbio et al., 2013), even if the biological role of SLC37A3 in pancreatic insulin secretion has never been clarified. Here, SLC37A3 is linked to congenital isolated hyperinsulinism.