FRG1 and Parkinson disease: Additionally, U1- the spliceosome component as well as RP11-462G22.1 (also known as lnc-FRG1-3 and the muscular dystrophy-associated lncRNA) were increased in both the brain and leukocytes of PD patients, suggesting that lncRNAs could also contribute to splicing modulations and muscle rigidity in PD.