This is exemplified by the population attributable risk (PAR=37.2%) calculated for three SNPs associated with the risk of sarcoma at a high level of evidence (rs11599754 of ZNF365/EGR2, rs231775 of CTLA4, and rs454006 of PRKCG), which indicates that more than one third of sarcoma cases would not occur in a hypothetical population where these three risk variants were absent. The gene discussed is PRKCG; the disease is sarcoma.