As an example, we considered the following three independent SNPs with high quality evidence on their relationship with sarcoma risk: rs11599754 of ZNF365/EGR2 (chromosome 10, risk allele: C, risk allele frequency in European ancestry population: 0.39, meta-analysis OR: 1.48); rs231775 of CTLA4 (chromosome 2, risk allele: A, risk allele frequency in European ancestry population: 0.65, meta-analysis OR: 1.36); and rs454006 of PRKCG (chromosome 19, risk allele: C, risk allele frequency in European ancestry population: 0.25, meta-analysis OR: 1.35). The gene discussed is PRKCG; the disease is sarcoma.