Finally, also somatic DNA alterations appear to confer a defective DNA repair capability to some sarcoma types such as Ewing's sarcoma [108], and thus the combinatory study of germline and somatic DNA variations characterizing sarcomas might lead to better understand the cascade of molecular events underlying sarcomagenesis, as recently proposed for the EWSR1-FLI1 fusion gene and the SNPs near EGR2 in Ewing's sarcoma patients [29]. The gene discussed is EWSR1; the disease is Ewing sarcoma.