In a next approach, we investigated the critical role of caspase-2 in HuR depletion-dependent sensitization of colon carcinoma cells to drug-induced apoptosis by employing Z-VDVAD-FMK, an inhibitor of caspases bearing a substrate which is preferentially cleaved by caspase-2 although these chemical inhibitors share similar cleavage motifs and therefore are not absolutely specific [24]. This evidence concerns the gene CASP2 and colon carcinoma.