Taken together, our findings indicate that chemotherapeutic drugs independent of their specific antitumor activity through activating HuR export and cytoplasmic caspase-2-5ʹUTR binding suppress IRES-dependent translation of caspase-2 presumably as part of a posttranscriptional survival program utilized by colon carcinoma cells. Here, CASP2 is linked to colon carcinoma.