A caspase-2-dependent increase in paclitaxel-induced caspase-3 cleavage upon siRNA-mediated knockdown of HuR was also found in HCT-15 cells (Supplementary Figure 2D) implicating that the sensitization of human colon carcinoma cells to apoptosis by HuR depletion is not a cell-type specific phenomenon. This evidence concerns the gene CASP2 and colon carcinoma.