NOTCH1 and acute lymphoblastic leukemia: Many aberrations in some signaling pathways are involved in ALLpathogenesis; amongst them, gain-of-function mutations in NOTCH1 genehave been described in more than 50% of T-cell acute lymphoblastic leukemia(T-ALL) cases, thus unraveling the role of Notch-mediated oncogenesis in lymphoidtissues.