Western blot analysis showed higher levels of Notch-1, Notch-3, Notch-4, Jagged-2 andDLL-4 expression in VR-ALL cell line (Figure 3).In general, molecular aberrations leading to ALGS, i.e mutations inJAGGED1 and NOTCH2, are mostly associated withdecreased Notch signaling [11]. This evidence concerns the gene NOTCH2 and acute lymphoblastic leukemia.