In this study, wedescribed the biological features of a new human B-ALL cell line derived from bonemarrow mononuclear cells of an ALGS patient affected by BCR-ABL-negative, common B-ALL.Flow-cytometric characterization revealed the B-ALL immunophenotype of VR-ALL cell line,with some antigen features in common with the pre-B-ALL cell line RS4;11. The gene discussed is ABL1; the disease is acute lymphoblastic leukemia.