B3GNT8 and malignant colon neoplasm: Intriguingly, our results also showed that highly expressed β3GnT8 in HCC tissues led to significantly increased levels of polylactosamines compared with the paracancer tissues (Figure 1), which is consistent with the previous report that β3Gn-T8 is involved in the biosynthesis of polylactosamine chains on β1,6-branched N-glycans and dramatically upregulated in colon cancer [6].