c-Jun has been found to be an important transcription factor regulating glycosylation-related genes in cancer development [18], and our laboratory has demonstrated that −561/+8 is a potential c-jun binding sequence on the β3GnT8 promoter via a luciferase reporter system [19], which prompted us to hypothesize that β3GnT8 is a direct downstream target of c-Jun in HCC. The gene discussed is JUN; the disease is cancer.