B3GNT8 and hepatocellular carcinoma: In the present study, we demonstrated that both β3GnT8 and polylactosamines were overexpressed in HCC tissues compared with the adjacent paracancer tissues, and investigated the role of β3GnT8 in the metastatic potential of HCC in vitro and tumorigenesis in vivo by gain- and loss-of-function assays.