We found a similar distribution with, for example, mutated TP53 in 4 out of 5 cell lines (71% mutated in HNSCC patients) and mutated CDKNA2 in two out of five cell lines (22% mutated, 60% gene copy loss in HNSCC patients) (Figure 1D) [38]. Here, TP53 is linked to head and neck squamous cell carcinoma.