The 475 mutated genes unique for responders, 733 for non-responders and 318 overlapping genes provided a significant basis to categorize HNSCC patients and allocate prosurvival, promitotic signaling pathways such as ErbB, TGF-β and adherens junction signaling to non-responders. This evidence concerns the gene TGFB1 and head and neck squamous cell carcinoma.