By reviewing the list of genes without impact like ERBB3, CASP8, RAF1 and KRAS (FaDu) as well as KEAP1, KRAS, RAF1 and FANCD2 (SAS), one finds tumor drivers ranked among the top 100 mutated genes in HNSCC [41, 42]. Here, CASP8 is linked to head and neck squamous cell carcinoma.