ARMS is characterized by the chromosomal translocation t (2;13) (q35; q14) or t (1;13) (q36; q14), which generate chimeric transcripts with the 5’ DNA binding site of the paired box protein 3 or 7 (PAX3 or PAX7) fused to the transactivation domain of a forkhead transcription factor (FKHR or FOXO), creating the novel PAX3-FOXO1 or PAX7-FOXO1 oncogenic fusion proteins [3, 4]. The gene discussed is PAX3; the disease is alveolar rhabdomyosarcoma.