Studies have shown that loss or a low level of EGR1 expression is observed in many human tumors, including breast carcinoma, non-small-cell lung cancer, hematopoietic malignancies, gliomas and sarcomas and that restoration of EGR1 can suppress proliferation and growth of these cells in vitro and in vivo, suggesting that EGR1 functions as a tumor suppressor [11, 12]. The gene discussed is EGR1; the disease is central nervous system cancer.