These findings, given the known ability of 2HF to decrease RLIP76 levels, when taken in the context of the role of RLIP76 in receptor-ligand signaling mediated by CDE and in pathogenesis of metabolic syndrome, provide promising evidence for 2HF and RLIP76 focused interventions for targeting both BC risk and progression [15, 47–48]. Here, RALBP1 is linked to breast cancer.