2HF at 5 and 10 μM concentrations led to inhibition of the survival of BC cells (MCF7: 16 ± 4 % and 23 ± 4 % at 5 and 10 μM 2HF, respectively; MDA-MB-231: 19 ± 4 % and 31 ± 6 % at 5 and 10 μM 2HF, respectively) and the addition of anti-RLIP76 IgG (10 μg/ml conc.)led to a stronger inhibition of BC cell survival (45 ± 6 % and 64 ± 6 % in MCF7 cells, and 52 ± 5 % and 72 ± 7 % in MDA-MB-231 cells, at 5 and 10 μM 2HF concentrations, respectively) (Figure 1A and 1B). This evidence concerns the gene RALBP1 and breast cancer.