With regard to HER2 status, the difference was significant, the OR among HER2+ women was 1.59 (1.15–2.22) for rs10490571, 0.72 (0.55–0.94) for rs3917318 were associated with BC risk, whereas that for HER2− women there was no significant SNPs. The gene discussed is ERBB2; the disease is breast cancer.