IL6 and colorectal carcinoma: Specifically, CRC patients have dysfunctional adipose tissue that might be a key contributor to the inflammatory state, by the secretion of several detrimental molecules such as tumor necrosis factor alpha (TNFA), interleukin-6 (IL6), and nuclear factor κ-light-chain-enhancer of activated B cells 1 (NFκB1) [12].