Thus, in PV such as in PF patients, the Dsg3 and Dsg1 epitope profiles remained stable over the disease course and, because of the rarity of ES, treatments based on the depletion or abrogation of autoantibodies to the N-terminal domains of Dsg3/Dsg1 should be promising (Figure 3B). Here, DSG1 is linked to pemphigus foliaceus.