In addition, in other diseases, such as polycystic ovary syndrome (PCOS) (10), adriamycin cardiomyopathy (11), and renal dysfunction (12), ANGPTL8 was also identified as a relevant modulator, which suggested additional functions of ANGPTL8 beyond the impacts on lipid and glucose metabolism. This evidence concerns the gene ANGPTL8 and polycystic ovary syndrome.