Recently,Coppola-Segovia et al. (2017) have presented a new model of PD, intranigral injection of Tunicamycin, in which the endoplasmic reticulum stressor recapitulates some of the phenotypic characteristics observed in rodent models of PD (such as locomotor impairment, α-synuclein oligomerization, and loss of dopaminergic neurons), reinforcing that endoplasmic reticulum stress could be an important contributor to the development of PD (Coppola-Segovia et al., 2017). Here, SNCA is linked to Parkinson disease.