In this review, we summarize the mutations of main seven genes (α-synuclein, LRRK2, PINK1, Parkin, DJ-1, VPS35 and GBA1) associated to PD and potential mechanisms for loss of dopaminergic neurons (dopamine metabolism, mitochondrial dysfunction, endoplasmic reticulum stress, impaired autophagy, and deregulation of immunity), and also expect the development direction for treatment of PD. This evidence concerns the gene PRKN and Parkinson disease.