It has been reported that the N-terminal acetylation of SNCA prevents its aggregation by stabilizing protein formation (Bartels et al., 2014), besides that, N-terminal acetylation can also act as a recognition tag to mediate protein degradation (Zattas et al., 2013), thus N-acetylation deficiency could be associated with PD pathogenesis. Here, SNCA is linked to Parkinson disease.