As the hippocampus is essential in contextual fear conditioning (Frankland et al., 1998; Maren et al., 2013) and the ventral hippocampus has been shown to play a role in the mechanisms of stress and anxiety (Bannerman et al., 2003, 2014), we reasoned that ADAR3 deficiency may affect hippocampal function. This evidence concerns the gene ADARB2 and Anxiety.