This behavior is enabled by a paracrine loop involving colony-stimulating factor 1 (CSF1) production by cancer cells, epidermal growth factor (EGF) production by TAMs, and release of hepatocyte growth factor (HGF) from endothelial cells (Leung et al., 2017, Patsialou et al., 2009, Wyckoff et al., 2004, Wyckoff et al., 2007). The gene discussed is CSF1; the disease is cancer.