Relative to those who tested negative for all markers, the risk for HCC among HBV DNA-positive participants who were HBsAg-positive or HBsAg-negative, was estimated at OR 34.48 (95% CI: 16.26–73.13) and OR 3.76 (95% CI: 1.79–7.92) respectively, with or without detectable anti-HBc. The gene discussed is KRT88P; the disease is hepatocellular carcinoma.