Considerably less attention has been paid to the S1P-degrading enzyme: sphingosine-1-phosphate lyase (SGPL1; EC 4.1.2.27) which irreversibly cleaves S1P into hexadecanal and ethanolamine phosphate and, is thus in a strategic position to regulate these processes by removing available S1P signaling pools, which means silencing the siren in order to prevent cancer cell migration to the blood vessels [7, 8]. Here, SGPL1 is linked to cancer.