Furthermore, several molecules involved in TGF-β-induced conversion of quiescent fibroblasts to activated myofibroblasts, such as focal adhesion kinase (FAK), hydrogen peroxide inducible gene 5 (HIC-5), myocardin-related transcription factor (MRTFA), and extracellular signal-regulated kinase 1/2 (ERK1), are regulated by Src and contribute to the persistent profibrotic phenotype of SSc fibroblasts [53–59]. The gene discussed is TGFB1; the disease is systemic sclerosis.