There are numerous risk prediction models for colorectal cancer (CRC) in the literature,[1,2] including both genetic[3–10] and non-genetic models.[11–22] The former only ascertains information from a small proportion of population that has inherited a genetic mutation related to several major genes, such as the MMR genes, APC, MUTYH, STK11 (LB1), BMPR1A, and PTEN. The gene discussed is PTEN; the disease is colorectal carcinoma.