As shown in Figure 6(C), the fluorescent intensity (total flux) of the HER2-LsbMDDs was primarily found at tumor sites (except in liver) and was 2 ∼ 3-fold higher than that for the LsbMDDs and DNS-LsbMDDs at 24 h, indicating higher accumulation of the HER2-LsbMDDs in the tumor. This evidence concerns the gene ERBB2 and neoplasm.