Indeed, the HER2-LsbMDDs produced a significantly higher cytotoxicity to the MCF-7/HER2 and SKBR-3 cancer cell lines, both of which overexpressed HER2 on cell membranes, but displayed similar cytotoxicity to MCF-7 (HER2-) which poorly expresses HER2 as those for Tynen®, the LsbMDDs, and DNS-LsbMDDs. Here, ERBB2 is linked to cancer.