ERBB2 and neoplasm: The uptake amount of the DIO-loaded HER2-LsbMDDs as shown in Figure 4(B) at all-time points was obviously greater than that for the LsbMDDs without BsAbs bound or bound with the isotype control antibody of the anti-DNS in HER2 over-presenting tumor cells of MCF-7/HER2 and SKBR-3, but not in MCF-7 tumor cells poorly presenting HER2.