There has been growing evidence of intrinsic myocardial dysfunction in patients with Marfan syndrome (MFS) caused by pathogenic variants in the FBN1 gene (Alpendurada et al., 2010; de Backer et al., 2006; Kiotsekoglou et al., 2008; Loeper et al., 2016; Rybczynski et al., 2007). This evidence concerns the gene FBN1 and Marfan syndrome.