INS and Hypoglycemia: These observations, along with acknowledgement of the high cost of measures aimed at reducing hypoglycaemia (i.e. structured education, psychological support, glucose self-monitoring, expensive glucose-lowering drugs associated with a lower risk of hypoglycaemia compared with sulfonylureas and insulin) [27–30], would point to the opposite hypothesis, underlying the relevance of socioeconomic status as a determinant of country differences.