PCK2 and metabolic dysfunction-associated steatotic liver disease: Thus, our integrated analyses of human NAFLD cases, including pathological scoring, biochemical data and gene expression data, and detailed comparisons with healthy controls enabled us to show that alterations in IRS-2, PEPCK and G6Pase expressions are concurrently induced in the early stage of NAFLD, when histological steatosis and lobular inflammation, but not ballooning and fibrosis, manifest.