The severities of steatosis and lobular inflammation correlated negatively with hepatic IRS-2 mRNA levels (r = −0.54, P < 0.01, and r = −0.35, P < 0.05, respectively) and positively with PEPCK (r = 0.38, P < 0.01, and r = 0.33, P < 0.05, respectively), and G6Pase (r = 0.50, P < 0.01, and r = 0.59, P < 0.01, respectively). Here, IRS2 is linked to steatosis.