KRAS and non-small cell lung carcinoma: Particularly, Shimamura et al. 29 reported that ganetespib induced the degradation of HSP90 client proteins, including both wild-type and mutant forms of EGFR, ErbB2, and KRAS, the induction of the pro-apoptotic factor Bim, and the downregulation of PI3K/Akt/mTOR and Raf/MEK/Erk signaling pathways in cell line and xenograft models of non-small cell lung cancer (NSCLC)29.